Nikos K Karamanos Selected Research

Proteoglycans (Proteoglycan)

1/2022	The microRNA-cell surface proteoglycan axis in cancer progression.
1/2020	Tumorigenic functions of serglycin: Regulatory roles in epithelial to mesenchymal transition and oncogenic signaling.
1/2020	Estrogen receptor-mediated targeting of the extracellular matrix network in cancer.
1/2019	Proteoglycans remodeling in cancer: Underlying molecular mechanisms.
12/2018	Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.
1/2017	Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.
1/2016	Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.
10/2015	Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.
4/2015	Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.
1/2015	Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.

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Nikos K Karamanos Research Topics

Disease

68	Neoplasms (Cancer) 10/2022 - 09/2002
35	Breast Neoplasms (Breast Cancer) 01/2022 - 09/2002
10	Neoplasm Metastasis (Metastasis) 05/2020 - 01/2008
7	Inflammation (Inflammations) 01/2019 - 01/2014
6	Carcinogenesis 01/2020 - 01/2011
6	Colonic Neoplasms (Colon Cancer) 01/2015 - 12/2007
6	Osteosarcoma (Osteogenic Sarcoma) 10/2011 - 01/2003
5	Triple Negative Breast Neoplasms 01/2022 - 05/2020
5	Pathologic Processes 01/2019 - 01/2010
4	Carcinoma (Carcinomatosis) 01/2019 - 07/2011
4	Lung Neoplasms (Lung Cancer) 01/2016 - 10/2009
4	Fibrosarcoma 02/2013 - 10/2009
3	Disease Progression 01/2020 - 01/2015
3	Melanoma (Melanoma, Malignant) 12/2011 - 06/2009
3	Atherosclerosis 01/2010 - 07/2002
2	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 02/2016
2	Infections 11/2015 - 05/2012
2	Seminoma 08/2014 - 01/2013
2	Colorectal Neoplasms (Colorectal Cancer) 08/2014 - 12/2007
2	Multiple Myeloma 05/2013 - 11/2006
2	Osteoarthritis 03/2008 - 06/2006
2	Vascular Diseases (Vascular Disease) 12/2002 - 07/2002
1	Glioma (Gliomas) 01/2021
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2021
1	Brain Neoplasms (Brain Tumor) 05/2020
1	Glioblastoma (Glioblastoma Multiforme) 05/2020

Drug/Important Bio-Agent (IBA)

24	Proteoglycans (Proteoglycan)IBA 01/2022 - 09/2002
17	Hyaluronic Acid (Hyaluronan)IBA 10/2022 - 01/2010
17	Estrogen ReceptorsIBA 01/2022 - 09/2002
12	GlycosaminoglycansIBA 12/2021 - 09/2002
11	Biological ProductsIBA 01/2020 - 07/2002
10	EnzymesIBA 10/2021 - 12/2007
10	Matrix Metalloproteinases (MMPs)IBA 01/2020 - 11/2006
8	Pharmaceutical PreparationsIBA 01/2022 - 06/2006
7	serglycinIBA 05/2020 - 11/2006
7	Fibronectins (Fibronectin)IBA 05/2020 - 02/2011
7	Protein Isoforms (Isoforms)IBA 12/2017 - 10/2009
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2010
6	Hormones (Hormone)IBA 01/2020 - 05/2013
6	SyndecansIBA 01/2017 - 11/2002
5	ErbB Receptors (EGF Receptor)IBA 01/2022 - 05/2013
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
5	Estrogens (Estrogen)FDA Link 05/2020 - 10/2008
5	DecorinIBA 01/2017 - 12/2002
5	Versicans (Versican)IBA 07/2011 - 11/2002
5	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2010 - 07/2002
4	Messenger RNA (mRNA)IBA 01/2022 - 11/2002
4	MicroRNAs (MicroRNA)IBA 01/2022 - 12/2017
4	Peptide Hydrolases (Proteases)FDA Link 03/2021 - 10/2010
4	Estradiol (Delestrogen)FDA LinkGeneric 12/2017 - 10/2008
4	BiglycanIBA 01/2017 - 12/2002
4	CollagenIBA 12/2016 - 05/2008
4	Epidermal Growth Factor (EGF)IBA 12/2016 - 05/2008
4	LumicanIBA 04/2014 - 01/2008
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2014 - 06/2009
4	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2013 - 06/2009
3	Small Interfering RNA (siRNA)IBA 01/2022 - 06/2009
3	Complement System Proteins (Complement)IBA 01/2021 - 01/2013
3	Collagen Type I (Type I Collagen)IBA 10/2020 - 01/2005
3	Phosphotransferases (Kinase)IBA 05/2020 - 11/2002
3	Estrogen Receptor alphaIBA 12/2017 - 10/2008
3	Insulin-Like Growth Factor I (IGF-1)IBA 12/2016 - 04/2004
3	Heparitin Sulfate (Heparan Sulfate)IBA 10/2015 - 05/2008
3	Syndecan-2IBA 05/2013 - 10/2008
3	Syndecan-4IBA 05/2013 - 06/2009
3	GlypicansIBA 05/2013 - 10/2010
3	Imatinib Mesylate (Gleevec)FDA Link 05/2013 - 12/2007
3	Peptides (Polypeptides)IBA 05/2010 - 12/2005
3	Tyrosine Kinase InhibitorsIBA 01/2008 - 11/2002
3	GenisteinIBA 04/2004 - 09/2002
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 05/2008
2	ChemokinesIBA 12/2018 - 01/2014
2	Interleukin-8 (Interleukin 8)IBA 12/2018 - 11/2015
2	Estrogen Receptor betaIBA 12/2017 - 12/2016
2	heparanaseIBA 01/2017 - 01/2014
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2016 - 11/2002
2	Syndecan-1 (Syndecan 1)IBA 01/2016 - 10/2015
2	CytokinesIBA 01/2014 - 01/2014
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2014 - 05/2013
2	Platelet-Derived Growth FactorIBA 01/2014 - 05/2013
2	Becaplermin (PDGF-BB)FDA Link 05/2013 - 01/2013
2	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 05/2013 - 05/2013
2	AerosolsIBA 04/2013 - 01/2012
2	Parathyroid Hormone (Parathormone)IBA 10/2011 - 05/2010
2	Small Leucine-Rich ProteoglycansIBA 06/2011 - 01/2008
2	Heparin (Liquaemin)FDA LinkGeneric 02/2011 - 05/2008
2	perlecanIBA 10/2010 - 11/2002
2	Dermatan SulfateIBA 01/2010 - 07/2002
2	ChondroitinIBA 05/2008 - 07/2002
2	Metalloproteases (Metalloproteinases)IBA 01/2008 - 11/2006
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2004 - 01/2003
2	IsoflavonesIBA 01/2003 - 09/2002
1	Bradykinin Receptors (Bradykinin Receptor)IBA 01/2021
1	FR 190997IBA 01/2021
1	BradykininIBA 01/2021
1	SalicylatesIBA 05/2020
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/2020

Therapy/Procedure

8	Therapeutics 01/2022 - 10/2009
4	Drug Therapy (Chemotherapy) 01/2022 - 09/2012
1	Precision Medicine 10/2022